Journal of natural products

Spirotetronate polyketides as leads in drug discovery

MH Lacoske, EA Theodorakis

Index: Kanchanabanca, Chompoonik; Tao, Weixin; Hong, Hui; Liu, Yajing; Hahn, Frank; Samborskyy, Markiyan; Deng, Zixin; Sun, Yuhui; Leadlay, Peter F. Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5785 - 5788 Angew. Chem., 2013 , vol. 125, # 22 p. 5897 - 5900,4

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Citation Number: 14

Abstract

... The precise mechanism for the elimination of the C-5 hydroxy group was recently elucidated by the Sun and Leadlay groups and shown to proceed via acetylation and subsequent elimination, thereby forming dienophile 19.(20) An intramolecular Diels–Alder (IMDA) reaction ...

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