1, 3, 5-Trialkyl-2, 4, 6-triiodobenzenes: Novel X-ray Contrast Agents for Gastrointestinal Imaging 1

…, JL Toner, D Mishra, WF Blazak, DM Miller…

Index: Estep, Kimberly G.; Josef, Kurt A.; Bacon, Edward R.; Illig, Carl R.; Toner, John L.; Mishra, Dinesh; Blazak, William F.; Miller, Dennis M.; Johnson, David K.; Allen, Jack M.; Spencer, Andy; Wilson, Susan A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 1940 - 1948

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Citation Number: 10

Abstract

Examination of the gastrointestinal (GI) tract has been performed for decades using barium sulfate. Although this agent has many recognized limitations including extreme radiopacity, poor intrinsic affinity for the GI mucosa, and very high density, no alternative contrast agents have emerged which produce comparable or better contrast visualization. In fact, the various techniques of the GI radiologic examination (ie, single contrast, double contrast, biphasic) ...