The Journal of Organic Chemistry

Silicon in synthesis. 21. Reagents for thiophenyl-functionalized cyclopentenone annulations and the total synthesis of (.+-.)-hirsutene

P Magnus, D Quagliato

Index: Magnus, Philip; Quagliato, Dominick Journal of Organic Chemistry, 1985 , vol. 50, # 10 p. 1621 - 1626

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Citation Number: 106

Abstract

Results The reagent 1 is readily available on a multigram scale by two routes. Addition of phenylsulfenyl chloride to vinyltrimethylsilane gave the adduct la which, on dehydrodehalogenation with DBU, provides 1. Treatment of 3 with LDA at-78 OC, followed by C1SiMe3, also gave 1. The full details of these procedures have previously been rep~ rted.~