Amination of Heterocyclic Compounds with O-Benzoylhydroxylamine Derivatives

…, RP Discordia, J Hynes, MM Miller, HR O'Grady…

Index: Parlanti, Luca; Discordia, Robert P.; Hynes Jr., John; Miller, Michael M.; O'Grady, Harold R.; Shi, Zhongping Organic Letters, 2007 , vol. 9, # 19 p. 3821 - 3824

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Citation Number: 12

Abstract

The N-amination of heterocyclic compounds 1a-k with O-benzoylhydroxylamine derivatives 5 was developed and demonstrated to be a superior alternative to existing N-amination methods. A structure-reactivity relationship study was performed on variously substituted O- benzoylhydroxylamine derivatives, leading to the discovery of the novel and more efficient aminating reagents 5h and 5i.