99m Tc/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral β-amyloid plaques

…, R Ikeoka, H Watanabe, H Kimura, T Fuchigami…

Index: Ono, Masahiro; Ikeoka, Ryoichi; Watanabe, Hiroyuki; Kimura, Hiroyuki; Fuchigami, Takeshi; Haratake, Mamoru; Saji, Hideo; Nakayama, Morio Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5743 - 5748

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Citation Number: 34

Abstract

Two 99mTc/Re complexes based on flavone and aurone were tested as potential probes for imaging β-amyloid plaques using single photon emission computed tomography. Both 99mTc-labeled derivatives showed higher affinity for Aβ (1–42) aggregates than did 99mTc- BAT. In sections of brain tissue from an animal model of AD, the Re-flavone derivative 9 and Re-aurone derivative 19 intensely stained β-amyloid plaques. In biodistribution ...