Chirality

Enantiopurity determination of the enantiomers of the triple reuptake inhibitor indatraline

SH Grimm, L Allmendinger, G Höfner, KT Wanner

Index: Grimm, Stefanie H.; Allmendinger, Lars; Hoefner, Georg; Wanner, Klaus T. Chirality, 2013 , vol. 25, # 12 p. 923 - 933

Full Text: HTML

Citation Number: 6

Abstract

ABSTRACT The present study describes the development of two approaches for the determination of the enantiopurity of both enantiomers of indatraline. Initially, a method was developed using different chiral solvating agents (CSAs) for diastereomeric discrimination regarding signal separation in 1 H nuclear magnetic resonance (NMR) spectroscopy, revealing MTPA as a promising choice for the differentiation of the indatraline enantiomers ...