Il Farmaco

Structure–activity relationship investigations of the modulating effect of core substituents on the affinity of pyrazoloquinolinone congeners for the benzodiazepine …

J Karolak-Wojciechowska, J Lange, W Książek…

Index: Karolak-Wojciechowska, Janina; Lange, Jerzy; Ksiazek, Waldemar; Gniewosz, Malgorzata; Rump, Slawomir Farmaco, 1998 , vol. 53, # 8-9 p. 579 - 585

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Citation Number: 6

Abstract

A series of 6-and 7-substituted-2-arylpyrazolo [4, 3-c] quinolin-3-ones was synthesized and tested in vitro for binding with the benzodiazepine receptor in competition with [3H] flunitrazepam. Electronic parameters (molecular electrostatic potential (MEP), charge distribution on the nitrogen atoms, dipole moment μ, and ionization potential (IP)) were calculated for the compounds by semi-empirical quantum chemistry methods. Lipophilicity ...