Antinociceptive properties of caffeic acid derivatives in mice

…, G Antonini, M Fracasso, V Cechinel Filho…

Index: de Campos Buzzi, Fatima; Franzoi, Caroline Liandra; Antonini, Graziele; Fracasso, Mauricio; Filho, Valdir Cechinel; Yunes, Rosendo Augusto; Niero, Rivaldo European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4596 - 4602

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Citation Number: 34

Abstract

Ten ester derivatives from caffeic acid were synthesized, and their antinociceptive properties are evaluated in mice. The most active compound, dodecyl ester derivative, exhibited potent and dose-related activity against the writhing test, with a calculated ID50 value of 15.1 (11.9– 19.1) μmol/kg and MI of 78.8% being several times more active than reference drugs. It was also effective in other experimental models, such as formalin, capsaicin and glutamate- ...