Inhibition of human acetyl-and butyrylcholinesterase by novel carbamates of (-)-and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine

…, SS Kulkarni, DA Parrish, HW Holloway…

Index: Luo, Weiming; Yu, Qian-Sheng; Holloway, Harold W.; Parrish, Damon; Greig, Nigel H.; Brossi, Arnold Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6171 - 6176

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Citation Number: 45

Abstract

A new enantiomeric synthesis utilizing classical resolution provided two novel series of optically active inhibitors of cholinesterase:(-)-and (+)-O-carbamoyl phenols of tetrahydrofurobenzofuran and methanobenzodioxepine. An additional two series of (-)-and (+)-O-carbamoyl phenols of pyrroloindole and furoindole were obtained by known procedures, and their anticholinesterase actions were similarly quantified against freshly ...