(E)-2-(3, 4-dimethoxyphenyl)-3-fluoroallylamine: a selective, enzyme-activated inhibitor of type B monoamine oxidase

P Bey, J Fozard, JM Lacoste, IA McDonald…

Index: Bey; Fozard; Lacoste; McDonald; Zreika; Palfreyman Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 9 - 10

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Citation Number: 52

Abstract

The search for clinically effective inhibitors of monoamine oxidase [amine: oxygen oxidoreductase (deaminating, flavin-containing); EC 1.4. 3.4; MA01 has been one of the continuing themes of drug research for the past 3 decades.'While the therapeutic advantages of MA0 inhibitors are generally well accepted, 2 one problem that has not yet been satisfactorily resolved is the so-called “cheese effe~ t”.~ An attractive approach to the ...