Water mediated deprotective intramolecular hydroamination of N-propargylaminopyridines: synthesis of imidazo [1, 2-a] pyridines

DC Mohan, NB Sarang, S Adimurthy

Index: Chandra Mohan, Darapaneni; Sarang, Niraj B.; Adimurthy, Subbarayappa Tetrahedron Letters, 2013 , vol. 54, # 45 p. 6077 - 6080

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Citation Number: 11

Abstract

Abstract Metal-free synthesis of substituted imidazole [1, 2-a] pyridines from deprotective N- (prop-2-yn-1-yl) pyridin-2-amines in water is elucidated. Electron releasing substituents on pyridine ring provided pure products in quantitative yields without separation by column chromatography.