Synthesis of 1, 3, 4??thiadiazol??2??ylacetic acid derivatives

…, N Saheki, M Hatanaka, T Ishimaru

Index: Saito; Saheki; Hatanaka; Ishimaru Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 73 - 75

Full Text: HTML

Citation Number: 7

Abstract

Abstract 1, 3, 4-Thiadiazol-2-ylacetic acids 4 were prepared by lithiation of 2-methyl-1, 3, 4- thiadiazoles 1, followed by treatment with carbon dioxide. Diethyl 1, 3, 4-thiadiazol-2- ylmalonates 6 were prepared by nucleophilic displacement reaction of the corresponding bromides 5 with diethyl malonate. Introduction of the amino group at the a-position of 4 or 6 was carried out via oximation or bromination to give the amino ester 9 or 4. Attempts to ...