Combining G??Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+ 1) PNA–DNA Bimolecular Quadruplex

…, P Sengupta, Y Krishnan, S Ladame

Index: Paul, Alexis; Sengupta, Poulami; Krishnan, Yamuna; Ladame, Sylvain Chemistry - A European Journal, 2008 , vol. 14, # 28 p. 8682 - 8689

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Citation Number: 38

Abstract

Abstract We describe the first G-quadruplex targeting approach that combines intercalation and hybridization strategies by investigating the interaction of a G-rich petide nucleic acid (PNA) acridone conjugate 1 with a three-repeat fragment of the human telomere G 3 to form a hybrid PNA–DNA quadruplex that mimicks the biologically relevant (3+ 1) pure DNA dimeric telomeric quadruplex. Using a combination of UV and fluorescence spectroscopy, ...