Synthesis of 4-arylcoumarins via Cu-catalyzed hydroarylation with arylboronic acids

Y Yamamoto, N Kirai

Index: Yamamoto, Yoshihiko; Kirai, Naohiro Organic Letters, 2008 , vol. 10, # 24 p. 5513 - 5516

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Citation Number: 75

Abstract

In the presence of 2− 4 mol% of CuOAc, methyl phenylpropiolates having a MOM-protected hydroxy group at the ortho position underwent hydroarylation with various arylboronic acids in MeOH at ambient temperature, resulting in the formation of 4-arylcoumarins in high yields after the acidic workup. This method was effectively used for the synthesis of biologically active natural and artificial compounds.