Total synthesis of (±)-mersicarpine

J Magolan, CA Carson, MA Kerr

Index: Magolan, Jakob; Carson, Cheryl A.; Kerr, Michael A. Organic Letters, 2008 , vol. 10, # 7 p. 1437 - 1440

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Citation Number: 86

Abstract

The first total synthesis of the indole alkaloid mersicarpine is reported. Key steps include a β- dicarbonyl radical cyclization, as well as an oxidation of the benzopyrrole moiety to establish the masked 1, 2-dicarbonyl functionality. An X-ray crystal structure and discussion of the 1H NMR behavior of the natural product are also presented.