… . XXXVII. A convenient synthesis and evaluation of anti??platelet aggregation activity of 1, 2, 4, 5??tetrahydro [1]??benzothiepino [4, 5??e] imidazo [1, 2??c] pyrimidine and …

T Nagamatsu, K Kinoshita, K Sasaki…

Index: Nagamatsu; Kinoshita; Sasaki; Nakayama; Hirota Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 513 - 515

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Citation Number: 11

Abstract

Abstract A simple and highly efficient methodology for the synthesis of 1, 2, 4, 5-tetrahydro [1] benzothiepino [4, 5-e]-imidazo [1, 2-c] pyrimidine (XI) having a novel ring system via 4- substituted 5, 6-dihydro [1] benzothiepino-[5, 4-d] pyrimidines VII-X is described. The anti- platelet aggregation activity for it and its related compounds against collagen-induced aggregation of rabbit blood platelets in vitro was found.