Structure and chemical properties of ptilomycalin A

…, T Kusumi, H Kakisawa, Y Kashman…

Index: Ohtani; Kusumi; Kakisawa; Kashman; Hirsh Journal of the American Chemical Society, 1992 , vol. 114, # 22 p. 8472 - 8479

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Citation Number: 108

Abstract

Abstract: The structure of ptilomycalin A (l), a marine alkaloid possessing potent antiviral and antibiotic activites, has been determined on the basis of NMR analyses of its trifluoroacetyl (TFA) derivative (2). It has a unique structure consisting of a polycyclic guanidine and a spermidine group, each of which is linked to a 16-hydroxyhexadecanoic acid moiety. The rotational isomerism of the acylated sperimidine moiety of 2 has been studied by ...