Organic letters

Copper (II) carboxylate promoted intramolecular diamination of terminal alkenes: improved reaction conditions and expanded substrate scope

TP Zabawa, SR Chemler

Index: Zabawa, Thomas P.; Chemler, Sherry R. Organic Letters, 2007 , vol. 9, # 10 p. 2035 - 2038

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Citation Number: 82

Abstract

The copper (II) carboxylate promoted diamination reaction has been improved by the use of the organic soluble copper (II) neodecanoate [Cu (ND) 2]. Cu (ND) 2 allowed the less-polar solvent dichloroethane (DCE) to be used, and as a consequence, decomposition of less- reactive substrates could be avoided. High diastereoselectivity was observed in the synthesis of 2, 5-disubstituted pyrrolidines. Ureas, bis (anilines), and α-amido pyrroles ...

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