Synthesis of 6-cyano-and 6-carbamoyl-purines and 6-carbamoyl-1, 2-dihydropurines from [MeC [triple bond, length as m-dash] NMe] O 3 SCF 3 and …

BL Booth, MF Proença

Index: Booth, Brian L.; Proenca, M. Fernanda Journal of the Chemical Society, Chemical Communications, 1981 , # 15 p. 788 - 789

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Citation Number: 10

Abstract

Diaminomaleonitrile reacts with N-methylace-tonitrilium trifluoromethanesulphonate to give, after base treatment, the 5-amino-4-(cyanoformimidoyl) imidazole (4) which forms 6- cyanopurines with carboxylic acid anhydrides, and with aldehydes, ketones, 1, 2-and 1, 3- diketones, and keto-esters gives 6-carbamoyl-1, 2-dihydro-purine derivatives from which 6- carbamoylpurines can be obtained.