A highly efficient and aerobic protocol for the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives via a palladium-catalyzed ligand-free Suzuki reaction

X Rao, C Liu, J Qiu, Z Jin

Index: Rao, Xiaofeng; Liu, Chun; Qiu, Jieshan; Jin, Zilin Organic and Biomolecular Chemistry, 2012 , vol. 10, # 39 p. 7875 - 7883

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Citation Number: 22

Abstract

A palladium-catalyzed aerobic and ligand-free Suzuki reaction in aqueous ethanol has been developed for the synthesis of N-heteroaryl substituted 9-arylcarbazolyl derivatives. A number of N-heteroaryl halides, namely 2-halogenated pyridines, 2-bromoquinoline, 5- bromopyrimidine and 2-chloropyrazine, were coupled with 4-(9H-carbazol-9-yl) phenylboronic acid (CPBA) or 9-phenyl-9H-carbazol-3-ylboronic acid (PCBA) efficiently to ...