An efficient procedure for the synthesis of formylacetic esters

S Edvinsson, S Johansson, A Larsson

Index: Edvinsson, Sofie; Johansson, Susanne; Larsson, Andreas Tetrahedron Letters, 2012 , vol. 53, # 50 p. 6819 - 6821

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Citation Number: 2

Abstract

An efficient synthesis of formylacetic esters via ozonolysis of trans-β-hydromuconic esters followed by a solid-supported triphenylphosphine reduction has been developed. In addition, an extension toward formylacetic amides and a one-pot preparation of more stable intermediates which can be used for further transformations are also described.