Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters

…, B Waldner, K Hilber, MD Mihovilovic

Index: Schnuerch, Michael; Waldner, Birgit; Hilber, Karlheinz; Mihovilovic, Marko D. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 7 p. 2149 - 2154

Full Text: HTML

Citation Number: 17

Abstract

A series of N-arylthiazole-2-amines was prepared and their biological activity for the promotion of skeletal muscle cell differentiation was investigated, a process of significant importance in muscle regeneration. A versatile new synthetic route towards the target compounds was developed and the substrate scope of this methodology was investigated. Introduction of the 2-aminoaryl substituent was carried out via nucleophilic substitution ...

Related Articles:

Polyarylated Thiazoles via a Combined Halogen Dance–Cross??Coupling Strategy

[Schnuerch, Michael; Khan, Ather Farooq; Mihovilovic, Marko D.; Stanetty, Peter European Journal of Organic Chemistry, 2009 , # 19 p. 3228 - 3236]

Optimization of the Conditions for Copper??Mediated N??Arylation of Heteroarylamines

[Liu, Yifeng; Bai, Yajun; Zhang, Juan; Li, Yangyang; Jiao, Junping; Qi, Xiaoli European Journal of Organic Chemistry, 2007 , # 36 p. 6084 - 6088]

Optimization of the Conditions for Copper??Mediated N??Arylation of Heteroarylamines

[Liu, Yifeng; Bai, Yajun; Zhang, Juan; Li, Yangyang; Jiao, Junping; Qi, Xiaoli European Journal of Organic Chemistry, 2007 , # 36 p. 6084 - 6088]

Polyarylated Thiazoles via a Combined Halogen Dance–Cross??Coupling Strategy

[Schnuerch, Michael; Khan, Ather Farooq; Mihovilovic, Marko D.; Stanetty, Peter European Journal of Organic Chemistry, 2009 , # 19 p. 3228 - 3236]

Reaction of 2-Amino-5-bromo-1, 3-thiazoles with Sodium 2-Hydroxyethoxide; Preparation of 2-Amino-3a, 5, 6, 7a-tetrahydro [1, 3] thiazolo [1, 4] dioxins

[Forlani,L. et al. Synthesis, 1977 , p. 320 - 322]

More Articles...