Tetrahedron letters

One-pot synthesis of polysubstituted indoles from aliphatic nitro compounds under mild conditions

CA Simoneau, AM Strohl, B Ganem

Index: Simoneau, Christopher A.; Strohl, Alexis M.; Ganem, Bruce Tetrahedron Letters, 2007 , vol. 48, # 10 p. 1809 - 1811

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Citation Number: 24

Abstract

Complex indoles are frequently synthesized by the classical Fischer method. Although historically limited to the condensations of aldehydes or ketones with arylhydrazines, the Fischer synthesis has recently been extended to the reactions of nitriles and carboxylic acids in 3-component reactions with arylhydrazines and organometallic reagents. 4 Here we describe an unexpectedly simple and effective one-pot synthesis of substituted indoles 2 from aliphatic nitro compounds 1, ...

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