Synthesis of α-amino acid derivatives by copper (I)-catalyzed conjugate addition of Grignard reagents to methyl 2-acetamidoacrylate

C Cardellicchio, V Fiandanese, G Marchese, F Naso…

Index: Cardellicchio, C.; Fiandanese, V.; Marchese, G.; Naso, F.; Ronzini, L. Tetrahedron Letters, 1985 , vol. 26, # 36 p. 4387 - 4390

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Citation Number: 28

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The reactions of Grignard reagents with methyl 2-acetamidoacrylate in the presence of CuI give fair to good yields of α-amino esters; the corresponding α-deutero- or α-methyl-derivatives are obtained upon quenching with D + or CH 3 I, respectively. ... For a comprehensive review ...