Design, synthesis, and biological evaluation of substituted 2, 3-dihydro-1H-cyclopenta [b] quinolin-9-ylamine related compounds as fructose-1, 6-bisphosphatase …

…, F Colizzi, V Andrisano, ML Bolognesi, P Hrelia…

Index: Rosini, Michela; Mancini, Francesca; Tarozzi, Andrea; Colizzi, Francesco; Andrisano, Vincenza; Bolognesi, Maria L.; Hrelia, Patrizia; Melchiorre, Carlo Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7846 - 7853

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Citation Number: 4

Abstract

In a search for structurally new inhibitors of fructose-1, 6-bisphosphatase (F16BPase), substituted 2, 3-dihydro-1H-cyclopenta [b] quinoline derivatives were synthesized. It has been shown that the 2, 3-dihydro-1H-cyclopenta [b] quinoline moiety may represent a suitable scaffold for the synthesis of potent F16BPase inhibitors endowed with significantly lower EGFR tyrosine kinase inhibitory activity.