Structural requirement of chalcones for the inhibitory activity of interleukin-5

HM Yang, HR Shin, SH Cho, SC Bang, GY Song…

Index: Yang, Hyun-Mo; Shin, Hye-Rim; Cho, Soo-Hyun; Bang, Seong-Cheol; Song, Gyu-Yong; Ju, Jung-Hun; Kim, Mi-Kyeong; Lee, Seung-Ho; Ryu, Jae-Chun; Kim, Youngsoo; Jung, Sang-Hun Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 104 - 111

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Citation Number: 57

Abstract

Novel chalcones were found as potent inhibitors of interleukin (IL)-5. 1-(2-Benzyloxy-6- hydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one (2b, 78.8% inhibition at 50μM, IC50= 25.3 μM) was initially identified as a potent inhibitor of IL-5. This shows the compatible activity with budesonide or sophoricoside. To identify structural requirements, 26 chalcones were prepared and their inhibitory activities were tested against IL-5. Among them, ...