A green chemistry method for the regeneration of carbonyl compounds from oximes by using cupric chloride dihydrate as a recoverable promoter for hydrolysis

N Quan, XX Shi, LD Nie, J Dong, RH Zhu

Index: Quan, Na; Shi, Xiao-Xin; Nie, Liang-Deng; Dong, Jing; Zhu, Rui-Heng Synlett, 2011 , # 7 p. 1028 - 1032

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Citation Number: 11

Abstract

Abstract A mild, efficient, general, and green method for the regeneration of carbonyl compounds from their corresponding oximes is described. Cupric salts promoted hydrolysis of oximes was studied, and the best reaction conditions for the hydrolysis have been found. Carbonyl compounds were obtained in 85-98% yields after the treatment of oximes with 2 molar equivalent of CuCl 2 2H 2 O at reflux (around 75 C) in a mixed solvent of acetonitrile ...