Helvetica chimica acta

Acridine??labeled primers as tools for the study of nonenzymatic RNA oligomerization

M Kurz, K Göbel, C Hartel, MW Göbel

Index: Kurz, Markus; Goebel, Karin; Hartel, Christian; Goebel, Michael W. Helvetica Chimica Acta, 1998 , vol. 81, # 6 p. 1156 - 1180

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Citation Number: 25

Abstract

Abstract Short, dye-labeled oligonucleotides have been used as primers in template- controlled polymerization reactions of RNA. The synthesis of appropriate acridine derivatives and their attachments to nucleic acids is described. In the nonenzymatic oligomerization of 2-methyl-1H-imidazole-activated guanosine 5′-monophosphate, two observations deserve special notice:(1) reaction rates are almost unchanged by variations ...