Tetrahedron letters

The first total synthesis of tetronasin (M139603)

K Hori, H Kazuno, K Nomura, E Yoshii

Index: Hori, Kozo; Kazuno, Hideki; Nomura, Keiichi; Yoshii, Eiichi Tetrahedron Letters, 1993 , vol. 34, # 13 p. 2183 - 2186

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Citation Number: 33

Abstract

Abstract Total synthesis tetronasin (1), a tetronic acid polyether ionophore antibiotic, is reported in which the γ-unsubstituted α-acyltetronic acid structure is constructed by cyclization of a β-keto ester derivative 18 derived from tricyclic aldehyde intermediate 17 by reaction with methyl (diazoacetoxy) acetate in the presence of zirconium tetrachloride.