CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound

…, M Meeson, M Stockley, TA Berkhout, J Gohil…

Index: Forbes, Ian T; Cooper, David G.; Dodds, Emma K.; Hickey, Deirdre M.B.; Ife, Robert J.; Meeson, Malcolm; Stockley, Martin; Berkhout, Theo A.; Gohil, Jayneeta; Groot, Pieter H.E.; Moores, Kitty Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1803 - 1806

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Citation Number: 64

Abstract

Over recent years, there has been a rapid growth in the number of isolated low molecular weight proteins called chemokines (chemotactic cytokines). 1 These proteins are involved in a variety of inflammatory responses via interaction with chemokine receptors located on the cell surface of leukocytes followed by chemotaxis and infiltration into the adjacent tissue. The chemokine proteins can be divided into four families dependent on the arrangement of conserved ...