Synthesis, biodistribution and antitumor activity of hematoporphyrin–platinum (II) conjugates

YS Kim, R Song, DH Kim, MJ Jun, YS Sohn

Index: Kim, Yeong-Sang; Song, Rita; Kim, Dong Hyun; Jun, Moo Jin; Sohn, Youn Soo Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1753 - 1760

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Citation Number: 61

Abstract

A new series of platinum (II) complexes of pegylated hematoporphyrin derivatives with controlled hydrophobic/hydrophilic balance were synthesized by introducing different kinds of poly (ethylene glycol) and amine ligands to the porphyrin ring. The antitumor activity of the porphyrin–platinum (II) conjugates was assayed in vitro and in vivo against leukemia L1210 cell line and various human tumor cell lines. The present complexes exhibited high ...