Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors

MR Shaaban, TS Saleh, AS Mayhoub…

Index: Shaaban, Mohamed R.; Saleh, Tamer S.; Mayhoub, Abdelrahman S.; Farag, Ahmad M. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3690 - 3695

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Citation Number: 34

Abstract

A simple, facile, efficient and one pot three-component procedure for the synthesis of pyrazolo [1, 5-a] pyrimidines, triazolo [1, 5-a] pyrimidines and pyrimido [1, 2-a] benzimidazoles ring systems incorporating phenylsulfonyl moiety was developed via the reaction of 1-aryl-2-(phenylsulfonyl) ethanone derivatives 1a–d with the appropriate heterocyclic amine and triethyl orthoformate and evaluated as Aurora-A kinase inhibitors. ...