Russian Journal of Bioorganic Chemistry

Polymethylene Derivatives of Nucleic Bases with ω-Functional Groups. III. 1 N-[7-(2-Oxocyclohexyl)-7-oxoheptyl]-Substituted Pyrimidines

AM Kritzyn, VV Komissarov

Index: Kritzyn; Komissarov Russian Journal of Bioorganic Chemistry, 2004 , vol. 30, # 5 p. 436 - 440

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Citation Number: 2

Abstract

We have previously shown that polymethylene derivatives of nucleic bases with various functional groups at the ω-position of their carbon chains (more than four carbon atoms in length) are convenient and promising tools for studying the enzymes of nucleic exchange [1, 2]. 3 For example, we found that such thymine and uracil derivatives can effectively interact with the reverse transcriptase site responsible for the recognition of the tRNALys anticodon and activate this enzyme. ...