Synthesis of the non-K-region dihydrodiols of 7-methylbenz [c] acridine

CC Duke, PT Murphy, GM Holder

Index: Duke, Colin C.; Murphy, Peter T.; Holder, Gerald M. Journal of Organic Chemistry, 1984 , vol. 49, # 23 p. 4446 - 4451

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Citation Number: 11

Abstract

The syntheses of the four non-K-region trans-dihydrodiols of 7-methylbenz [c] acridine (2) are described. The trans-8, 9-and-10, ll-dihydrodiols 13 and 16 were prepared from 7-methyl- 8, 9, 10, 11-tetrahydrobenz [c] acridine (3) via the trans-8, 9-diacetoxy-7-methyl-8, 9, lO, ll- tetrahydrobenz [c] acridine (10) and its l0, ll-isomer (14) by selective benzylic bromination followed by dehydrobromination. The trans-tetrahydro diacetates were obtained through ...