The chemistry of alkyl thiosulfate esters. 8.(E, Z)-Ajoene: a potent antithrombotic agent from garlic

E Block, S Ahmad, MK Jain, RW Crecely…

Index: Block; Ahmad; Jain; et al. Journal of the American Chemical Society, 1984 , vol. 106, # 26 p. 8295 - 8296

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Citation Number: 235

Abstract

Apitz-Castro et al. 4a reported that 2-vinyl-4H-1, 3-dithiin (7) and an unknown compound, now named aj~ ene,~~ are potent antithrombotic agents derived from garlic extract. Unlike several other inhibitors of platelet aggregation, these components have been found to inhibit aggregation induced by all known inductors. 4a We report herein the structural characterization and a simple synthesis of (E, Z)-ajoene (4) as well as 7 from allicin (1). ...

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