Asymmetric Hydrogenation with Highly Active IndolPhos–Rh Catalysts: Kinetics and Reaction Mechanism

J Wassenaar, M Kuil, M Lutz, AL Spek…

Index: Wassenaar, Jeroen; Kuil, Mark; Lutz, Martin; Spek, Anthony L.; Reek, Joost N. H. Chemistry - A European Journal, 2010 , vol. 16, # 22 p. 6509 - 6517

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Citation Number: 35

Abstract

Abstract The mechanism of the IndolPhos–Rh-catalyzed asymmetric hydrogenation of prochiral olefins has been investigated by means of X-ray crystal structure determination, kinetic measurements, high-pressure NMR spectroscopy, and DFT calculations. The mechanistic study indicates that the reaction follows an unsaturate/dihydride mechanism according to Michaelis–Menten kinetics. A large value of KM (KM= 5.01±0.16 M) is ...