A Mild and Versatile Method for the Synthesis of Alkyl Ethers from Methoxymethyl Ethers and Application to the Preparation of Sterically Crowded Ethers

Y Minamitsuji, A Kawaguchi, O Kubo…

Index: Minamitsuji, Yutaka; Kawaguchi, Atsuhisa; Kubo, Ozora; Ueyama, Yoshifumi; Maegawa, Tomohiro; Fujioka, Hiromichi Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 1861 - 1866

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Citation Number: 5

Abstract

Abstract A mild and divergent route for the synthesis of alkyl ethers from methoxymethyl (MOM) and methoxyethyl (ME) ether derivatives via pyridinium-type salt intermediates has been developed. The addition of organocuprates to the salts afforded the corresponding alkyl ethers, including highly crowded ones, in high yields even in the presence of acid-or base-sensitive functional groups.

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