Antiestrogenic properties of substituted benz [a] anthracene-3, 9-diols

…, SL Schneider, RE Bronstein, J Dawidzik

Index: Morreal, Charles E.; Sinha, Dilip K.; Schneider, Sara L.; Bronstein, Robert E.; Dawidzik, Jean Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 323 - 326

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Citation Number: 10

Abstract

The antiestrogenic potency of benz [a] anthracene-3, 9-diol, as well as its 7-and 12-methyl derivatives, was evaluated by measuring the inhibition in the onset of estrus brought about by this compound in ovariectomized rats treated with 178-estradiol. At a dose of 0.5 mg the 7, 12-dimethyl derivative caused a decrease in the percentage of rats in estrus from 78 to 44%. This decrease is identical with that caused by 0.05 mg of nafoxidine.