Studies on antibiotics and related substances. X. Syntheses of some unsaturated ketocarboxylic acids, anti-tumor substances

M Kinoshita, S Umezawa

Index: Kinoshita,M.; Umezawa,S. Bulletin of the Chemical Society of Japan, 1960 , vol. 33, p. 1075 - 1080

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Citation Number: 9

Abstract

1) 2-(Dimethylaminomethyl)-3-ketobutane-1-carboxylic acid hydrochloride (VI) as well as 5- dimethylamino-3-ketopentane-1-carboxylic acid hydrochloride (I) has been obtained from levulinic acid, paraformaldehyde and dimethylamine hydrochloride by means of the Mannich reaction. Thermal degradation of I and VI afforded δ-methylenelevulinic acid (IV) and β-methylenelevulinic acid (VII), respectively. 2) 3-(Dimethylaminomethyl)-4- ...