Sterically hindered 5, 11-dicarbo analogs of clozapine as potential chiral antipsychotic agents

JH Rupard, T De Paulis, A Janowsky…

Index: Rupard, J. Howard; Paulis, Tomas de; Janowsky, Aaron; Smith, Howard E. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2261 - 2268

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Citation Number: 26

Abstract

Sterically hindered 5, ll-dicarbo analogues of clozapine were prepared as potential chiral antipsychotic agents, with the possibility that for a particular analogue the antipsychotic activity of clozapine may reside in one enantiomer of the analogue whereas other unwanted biological effects of clozapine may be caused by the other enantiomer. Variable-temperature proton nuclear magnetic resonance studies showed that although 5-methylene-l0-(4- ...