Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor
H Yin, W Zhu, Y Xu, M Dai, X Qian, Y Li, J Liu
Index: Yin, Hong; Zhu, Weiping; Xu, Yufang; Dai, Min; Qian, Xuhong; Li, Yuanli; Liu, Jianwen European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3030 - 3037
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Citation Number: 19
Abstract
Abstract A series of novel aliphatic N-oxide of naphthalimides (A1–A5) were designed and prepared. The N–O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was ...
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