Sensitive Near??Infrared Fluorescent Probes for Thiols Based on Se N Bond Cleavage: Imaging in Living Cells and Tissues

R Wang, L Chen, P Liu, Q Zhang…

Index: Wang, Rui; Chen, Lingxin; Liu, Ping; Wang, Yunqing; Zhang, Qin Chemistry--A European Journal, 2012 , vol. 18, # 36 p. 11343 - 11349,7

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Citation Number: 56

Abstract

Abstract Cy-NiSe and Cy-TfSe were designed and synthesized as sensitive near-infrared (NIR) fluorescent probes for detecting thiols on the basis of Se [BOND] N bond cleavage both in cells and in tissues. Since a donor-excited photoinduced electron transfer (d-PET) process occurs between the modulator and the fluorophore, Cy-NiSe and Cy-TfSe have weak fluorescence. On titration with glutathione, the free dye exhibits significant ...