Tetrahedron letters

A new type of nucleotide analogue with 4-pyridylphosphonate internucleotide linkage

A Kers, J Stawiński

Index: Kers, Annika; Stawinski, Jacek Tetrahedron Letters, 1999 , vol. 40, # 22 p. 4263 - 4266

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Citation Number: 25

Abstract

Suitably protected dithymidine H-phosphonates were quantitatively converted into the corresponding dinucleoside 4-pyridylphosphonates by treatment with 1, 8-diazabicylo [5.4. 0] undec-7-ene (DBU) in the presence of trityl chloride in pyridine. The reaction was found to be stereospecific and proceeded, most likely, with retention of configuration at the phosphorus centre.

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