Efficient one-pot synthesis of biologically active polysubstituted aromatic amines

D Menche, F Arikan, J Li, S Rudolph, F Sasse

Index: Menche, Dirk; Arikan, Fatih; Li, Jun; Rudolph, Sven; Sasse, Florenz Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 23 p. 7311 - 7317

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Citation Number: 10

Abstract

An efficient and modular one-pot synthesis of polysubstituted aromatic amines by a mild reductive amination procedure is described and the biological potential of these nitrogen- centered compounds is demonstrated by growth inhibition of murine connective tissue cells and microscopy-based morphological studies.