A 'click chemistry'approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging

…, C Vitry, T Bordenave, M Szlosek-Pinaud, E Fouquet

Index: James, Damien; Escudier, Jean-Marc; Amigues, Eric; Schulz, Juergen; Vitry, Christiane; Bordenave, Thomas; Szlosek-Pinaud, Magali; Fouquet, Eric Tetrahedron Letters, 2010 , vol. 51, # 8 p. 1230 - 1232

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Citation Number: 25

Abstract

Different thymidine derivatives bearing either an iodoaryl moiety at the 5′ position or a dialkylsilyl group at the 3′ position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11.