Host-[2] rotaxanes as cellular transport agents

V Dvornikovs, BE House, M Kaetzel…

Index: Dvornikovs, Vadims; House, Brian E.; Kaetzel, Marcia; Dedman, John R.; Smithrud, David B. Journal of the American Chemical Society, 2003 , vol. 125, # 27 p. 8290 - 8301

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Citation Number: 55

Abstract

Host-[2] rotaxanes, containing a diarginine-derivatized dibenzo-24-crown-8 (DB24C8) ether as the ring and a cyclophane pocket or an aromatic cleft as one blocking group, are cell transport agents. These hosts strongly associate with a variety of amino acids, dipeptides, and fluorophores in water (1 mM phosphate buffer, pH 7.0), DMSO, and a 75/25 (v/v) buffer to DMSO solution. All peptidic guests in all solvent systems have association constants (K ...

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