Syntheses of 3, 3-dimethyl-2-hydroxybutyric acid and tertiary leucine and their optical resolutions

T Tanabe, S Yajima, M Imaida

Index: Tanabe,T. et al. Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 2178 - 2179

Full Text: HTML

Citation Number: 15

Abstract

DL-3, 3-Dimethyl-2-hydroxybutyric acid (I) was prepared by the reduction of trimethylpyruvic acid (II) with sodium amalgam1) and by catalytic hydrogenation with palladium black. 2'The optical resolution of I has not yet been attempted, however. DL-t-Leucine (III) was prepared by the reduction of trimethylpyruvic acid oxime8'and resolved into its optical isomers by the treatment of the N-formyl derivative of III with brucine. 4) The absolute configuration of the ( ...

Related Articles:

Bismuth (III) Triflate-Catalyzed Synthesis of Substituted 2-Alkenylfurans

[Nitsch, Dominik; Huber, Stefan M.; Poethig, Alexander; Narayanan, Arjun; Olah, George A.; Prakash, G. K. Surya; Bach, Thorsten Journal of the American Chemical Society, 2014 , vol. 136, # 7 p. 2851 - 2857]

Stereospecific α-methallylation of hydroxyaldehydes by silatropic ene cyclisation

[Robertson, Jeremy; Hall, Michael J.; Green, Stuart P. Tetrahedron, 2009 , vol. 65, # 28 p. 5541 - 5551]

The design and synthesis of inhibitors of pantothenate synthetase

[Tuck, Kellie L.; Saldanha, S. Adrian; Birch, Louise M.; Smith, Alison G.; Abell, Chris Organic and Biomolecular Chemistry, 2006 , vol. 4, # 19 p. 3598 - 3610]

Reaction of ketene bis (trimethylsilyl) acetals with m-chloroperbenzoic acid. Synthesis of. alpha.-hydroxycarboxylic acids

[Rubottom,G.M.; Marrero,R. Journal of Organic Chemistry, 1975 , vol. 40, p. 3783 - 3784]

Cyclic peroxides. 52.. alpha.-Peroxylactones via dehydrative cyclization of. alpha.-hydroperoxy acids

[Adam,W. et al. Journal of the American Chemical Society, 1977 , vol. 99, # 17 p. 5768 - 5773]

More Articles...