Synthesis and biological evaluation of trifluralin analogues as antileishmanial agents

MA Esteves, I Fragiadaki, R Lopes, E Scoulica…

Index: Esteves; Fragiadaki; Lopes; Scoulica; Cruz Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 274 - 281

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Citation Number: 16

Abstract

A series of new analogues of trifluralin (TFL) were synthesized and characterized in view of changing the unfavorable properties that limits its use as antileishmanial agent. Some of the TFL analogues display more activity than a standard drug (miltefosine) against the promastigote forms of Leishmania infantum and Leishmania donovani and the intracellular form (THP-1 infected with L. infantum). All analogues showed a clear advantage over ...