Russian journal of organic chemistry

A convenient procedure for preparation of 1-(1-aminoalkyl)-1-cyclopropanols from N-benzyl α-amino acid esters

IL Lysenko, OG Kulinkovich

Index: Lysenko; Kulinkovich Russian Journal of Organic Chemistry, 2001 , vol. 37, # 9 p. 1238 - 1243

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Citation Number: 6

Abstract

Abstract The reaction of N-benzyl α-amino acid ethyl esters with ethylmagnesium bromide in the presence of a catalytic amount of titanium tetraisopropoxide leads to formation of the corresponding 1-aminoalkyl-1-cyclopropanols in high yields. Hydrogenation of the latter over palladium catalyst ensures selective removal of one or two protecting benzyl groups from the nitrogen atom.