Synthesis and evaluation of novel heterocyclic MMP inhibitors

R Hayashi, X Jin, GR Cook

Index: Hayashi, Ryuji; Jin, Xiaomin; Cook, Gregory R. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6864 - 6870

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Citation Number: 23

Abstract

A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone- based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.